Keywords
Tuberculosis
type 2 diabetes mellitus
ICAM-I
serum levels
risk factors.
type 2 diabetes mellitus
ICAM-I
serum levels
risk factors.
How to Cite
Aslam, Z., Mumtaz, M., & Malkani, N. (2019). Evaluation of Serum Circulating Levels of ICAM-1 as Tuberculosis Risk-assessment Factor in Type 2 Diabetes Patients. Puerto Rico Health Sciences Journal, 38(1), 22–26. Retrieved from https://prhsj.rcm.upr.edu/index.php/prhsj/article/view/1798
Abstract
Objective: Type 2 diabetes mellitus, due to its deteriorating effect on the immune system, makes a person susceptible to various other diseases, such as tuberculosis. The alarming increase in the number of diabetes mellitus cases in Pakistan may be a contributing factor to the increased tuberculosis incidence. The expression of cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) is important in determining cell permeability, and the latter’s altered expression may ease the entry of infectious agents into the cell. Therefore, the present study evaluated the role of ICAM-1 in type 2 diabetes and tuberculosis patients so that a potential link between these 2 epidemics could be found. Methods: To explore this hypothesis, the expression of ICAM-1 was measured tested in 3 groups of subjects: group I consisted of 100 healthy individuals (control), group II consisted of 100 type 2 diabetics, and group III consisted of 100 individuals with both type 2 diabetes and tuberculosis. Demographic information was obtained from all the participants and compared by group and ICAM-1 levels in the blood were determined by ELISA. Results: The results revealed that, in comparison to group I, the individuals of group II had significantly (p ≤ 0.05) increased levels of ICAM-1, making them more prone to infection (by promoting the increased invasion of mycobacterium) and hence at increased risk of contracting tuberculosis. Conclusion: In conclusion, the present study demonstrated that elevated levels of ICAM-1 in patients with type 2 diabetes mellitus are likely associated with the development of tuberculosis.
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