Keywords
Osteoprotegerin
Periodontitis
plasma
Periodontitis
plasma
How to Cite
García-Parra, M. I., Jiménez-Coello, M., Carrillo-Ávila, B. A., Hernández-Cortázar, I., Chávez-Cortez, G., & Martínez-Aguilar, V. M. (2022). Quantification of Osteoprotegerin Plasma Levels in Patients with Periodontitis. Puerto Rico Health Sciences Journal, 41(1), 5–8. Retrieved from https://prhsj.rcm.upr.edu/index.php/prhsj/article/view/2443
Abstract
Objective: Periodontitis (POD) is an infectious process directed at the structures supporting the teeth. Destruction of alveolar bone is considered one of the main causes of tooth loss in humans and is mediated by the host immune response. Osteoprotegerin (OPG), a protein that inhibits bone resorption by binding to the RANK ligand (RANKL), prevents osteoclastic differentiation. The aim of the study was to determine the plasma levels of OPG in patients with POD. Methods: a case-control study with forty-nine patients with POD and 49 healthy controls were included in the study. OPG levels were determined by an ELISA test in plasma samples. Results: OPG values (1.6203 ng/mL) were higher in the POD group compared with control group (1.2824 ng/mL). Among the studied groups, we detected significant differences in age, glycosylated haemoglobin (HbA1C), and plasma concentration of OPG (p < 0.05). Conclusion: plasma OPG levels are associated with bone formation and destruction processes, suggesting that OPG acts in a protective manner.
Authors who publish with this journal agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).