Clinicopathological Factors associated to Her-2 Status in a Hospital-based Sample of Breast Cancer Patients in Puerto Rico
Vol. 29 No. 3 (2010), Original Study
Vol. 29 No. 3 (2010)

Clinicopathological Factors associated to Her-2 Status in a Hospital-based Sample of Breast Cancer Patients in Puerto Rico

Original Study
Published 2010-08-03
Ana P. Ortiz
Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center; Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University Of Puerto Rico
Orquídea Frías
University of Puerto Rico Cancer Center
Carmen González-Keelan
Department of Pathology, School of Medicine, Medical Sciences Campus, University of Puerto Rico
Erick Suárez
Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico
David Capó
Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico
Javier Pérez
Puerto Rico Central Cancer Registry, University of Puerto Rico Comprehensive cancer Center
Fernando Cabanillas
Puerto Rico Central Cancer Registry, University of Puerto Rico Comprehensive Cancer Center; Cancer Center, Hospital Auxilio Mutuo
Edna Mora
Department of Surgery, Medical Sciences Campus, University of Puerto Rico; University of Puerto Rico Comprehensive Cencer Center
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Keywords

Breast cancer
Her-2 neu
Puerto Rico

How to Cite

Ortiz, A. P., Frías, O., González-Keelan, C., Suárez, E., Capó, D., Pérez, J., … Mora, E. (2010). Clinicopathological Factors associated to Her-2 Status in a Hospital-based Sample of Breast Cancer Patients in Puerto Rico. Puerto Rico Health Sciences Journal, 29(3). Retrieved from https://prhsj.rcm.upr.edu/index.php/prhsj/article/view/445
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Abstract

Breast cancer is the most common female malignancy in Puerto Rico. Cases with human epidermal growth factor receptor 2 (HER-2) oncoprotein overamplification are associated with aggressive clinical behavior. Given the limited availability of information for Puerto Rico, we aimed to evaluate the prevalence and clinical correlates of HER-2 gene overexpression among a hospital-based female population of breast cancer cases. We analyzed data from 1,049 female patients with invasive breast cancer (diagnosed 2000-2005) at the I. González Martínez Oncologic Hospital and the Auxilio Mutuo Hospital. HER-2 status and other clinical characteristics were retrieved from the hospitals’ cancer registries, from the Puerto Rico Central Cancer Registry, and from a review of medical and pathological records. Prevalence odds ratios were estimated with 95% confidence intervals, using logistic regression models to quantify the association between HER-2 status and different clinicophatological factors. The overall prevalence of positive HER-2 expression was 22.5%. In the multivariate logistic regression model, factors significantly associated with HER-2 positivity included a diagnosis age of < 50 years, having a tumor with negative progesterone receptor (PR) status, and having regional disease (p < 0.05). No significant differences in HER-2 positivity were observed by tumor histology or estrogen receptor (ER) status (p > 0.05). This is the most comprehensive epidemiological study to date on HER-2 status in Puerto Rico. The prevalence and correlates of HER-2 overexpression in this study are comparable to those observed in US populations. Study results will aid in the development of breast cancer control strategies in Puerto Rico.
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