Palabras clave
Etomidate
Alpha-2B receptor
Hemodynamic profile
Alpha-2B receptor
Hemodynamic profile
Cómo citar
Creagh, O., Torres, H., Rodríguez, N., & Gatica, S. R. (2010). Alpha-2B Adrenergic Receptor Mediated Hemodynamic Profile of Etomidate. Puerto Rico Health Sciences Journal, 29(2). Recuperado a partir de https://prhsj.rcm.upr.edu/index.php/prhsj/article/view/277
Resumen
Etomidate has been used since 1972 as an inductor and maintaining anesthesia. There are multiple mechanisms that account for the biologic effects of Etomidate. One of the most prominent features of this drug is to provide anesthesia without gross changes in hemodynamic parameters. This feature allows using Etomidate in patients with considerable cardiopulmonary compromise avoiding the characteristic hypotension produced by other anesthetics. A mechanism that provide basis for its cardiovascular stability is the capacity to bind and stimulate peripheral alpha-2B adrenergic receptors with a subsequent vasoconstriction. Alterations in the function or number of these receptors may account for abnormal responses during Etomidate induction.
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