Keywords
Fluoride
Morphological change
Cardiomyocytes
Mitochondria
Ca2 concentration
Morphological change
Cardiomyocytes
Mitochondria
Ca2 concentration
How to Cite
Limon-Rojas, A., Pozos-Guillén, A., Salgado-Delgado, R., Rodríguez y Domínguez, M., & Escobar-García, D. M. (2023). Morphological changes and Mitochondrial alterations on Cardiomyocytes exposed to Fluoride. Puerto Rico Health Sciences Journal, 42(2), 132–138. Retrieved from https://prhsj.rcm.upr.edu/index.php/prhsj/article/view/2773
Abstract
Objective: To evaluate the morphological changes of cardiomyocytes exposed to different sodium fluoride (NaF) concentrations, as well as to evaluate the behavior of the mitochondria. Methods: Rat H9c2 cardiomyocytes were exposed to NaF at concentrations of 0.5 to 5 mmol/L. The morphology and number of mitochondria in these cells were monitored, and the calcium ion (Ca2+) concentration was determined. Results: Morphological changes were evident in the cells treated with different NaF concentrations, and both the number of mitochondria and the Ca2+ concentration decreased in a dose-dependent manner. Conclusion: Sodium fluoride induced morphological damage in cardiomyocytes, decreases the Ca2+ concentration and mitochondrial number.
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