Morphological changes and Mitochondrial alterations on Cardiomyocytes exposed to Fluoride

Areli Limon-Rojas, Amaury Pozos-Guillén, Roberto Salgado-Delgado, Margarita Rodríguez y Domínguez, Diana María Escobar-García


Objective: To evaluate the morphological changes of cardiomyocytes exposed to different sodium fluoride (NaF) concentrations, as well as to evaluate the behavior of the mitochondria. Methods: Rat H9c2 cardiomyocytes were exposed to NaF at concentrations of 0.5 to 5 mmol/L. The morphology and number of mitochondria in these cells were monitored, and the calcium ion (Ca2+) concentration was determined. Results: Morphological changes were evident in the cells treated with different NaF concentrations, and both the number of mitochondria and the Ca2+ concentration decreased in a dose-dependent manner. Conclusion: Sodium fluoride induced morphological damage in cardiomyocytes, decreases the Ca2+ concentration and mitochondrial number.


Fluoride; Morphological change; Cardiomyocytes; Mitochondria, Ca2+ concentration

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